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The trial of the only weakened virus covid-19 vaccine starts. Will we see a France-Germany clash?

VLA2001, the anti-covid vaccine from the French company Valneva , has started phase 3 tests in the UK, for which results are currently expected at the beginning of the fourth quarter of 2021. approval by the British drug control body at the end of 2021. This obviously if the vaccine is effective and proves to be actually harmless.

In September 2020, Valneva announced a partnership with the UK government, which has the ability to purchase up to 190 million doses by 2025. So far, the UK government has ordered 100 million doses for supply in 2021. and in 2022, by which time the vaccine should be definitively approved.

What differentiates the French Valnevia from the currently popular mRNA vaccines, i.e. Pfizer and Moderna? Which is based, like all traditional vaccines, on complete inactivated viruses, not on RNA fragments that induce a production of proteins which then, in turn, cause antibodies to be produced. So it is the whole virus, rendered harmless, that induces the immune response, not a single protein. VLA2001 is manufactured on Valneva's established Vero-cell platform, leveraging manufacturing technology for Valneva's licensed Japanese encephalitis vaccine, IXIARO®. VLA2001 consists of inactivated whole viral particles of SARS-CoV-2 with a high density of S proteins, in combination with two adjuvants, alum and CpG 1018.

at this time we are talking about a "booster" of Pfizer vaccines, while the inactivated vaccine, produced on a traditional platform, should provide much broader coverage because the immune response does not focus, as with mRNA, on a single protein, but is more comprehensive and covers more aspects of the virus. This should make the vaccine less sensitive to variants as well.

All this, however, raises some questions:

  • Will we see a trade war between a French vaccine, developed mainly for the UK, and a German one later produced by the Americans? Probably yes, and Pfizer will try to download as much vaccine as possible before it becomes obsolete;
  • when pharmaceutical science is evolving so rapidly, does it make sense to impose a vaccination obligation by law which, by its very nature, risks being overtaken by technological advancement?

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The article The trial of the only weakened virus covid-19 vaccine starts. Will we see a France-Germany clash? comes from ScenariEconomici.it .


This is a machine translation of a post published on Scenari Economici at the URL https://scenarieconomici.it/parte-la-sperimentazione-dellunico-vaccino-covid-19-da-virus-indebolito-vedremo-uno-scontro-francia-germania/ on Tue, 24 Aug 2021 09:00:26 +0000.